American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship - Stefan Kathman

    Project: Research project

    Project Details

    Description

    We have identified the first known specific inhibitors of the ubiquitin ligase
    Nedd4-1 using irreversible tethering. We will continue to optimize these inhibitors until they are suitable for cell based
    studies of Nedd4-1 function. We are most interested in studying whether our inhibitors can
    impair PTEN polyubiquitination and degradation but preserve monoubiquitination, which is
    essential for nuclear localization.
    StatusFinished
    Effective start/end date9/1/148/31/15

    Funding

    • American Chemical Society (Letter 06/15/14)

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