American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship - Stefan Kathman

  • Statsyuk, Alexander Vladimirovich (PD/PI)

Project: Research project

Project Details


We have identified the first known specific inhibitors of the ubiquitin ligase Nedd4-1 using irreversible tethering. We will continue to optimize these inhibitors until they are suitable for cell based studies of Nedd4-1 function. We are most interested in studying whether our inhibitors can impair PTEN polyubiquitination and degradation but preserve monoubiquitination, which is essential for nuclear localization.
Effective start/end date9/1/148/31/15


  • American Chemical Society (Letter 06/15/14)


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