American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship - Stefan Kathman

We have identified the first known specific inhibitors of the ubiquitin ligase Nedd4-1 using irreversible tethering. We will continue to optimize these inhibitors until they are suitable for cell based studies of Nedd4-1 function. We are most interested in studying whether our inhibitors can impair PTEN polyubiquitination and degradation but preserve monoubiquitination, which is essential for nuclear localization.