An intravascular Islet delivery and recovery device

Intravascular Retrievable Cell Delivery System for Islet Transplantation Abstract: Diabetes mellitus type 1 (T1D) is a chronic condition characterized by the autoimmune-mediated destruction of pancreatic β-cells within the islets of Langerhans. Islets transplantation in the liver often results in limited islets survival due to abnormal blood flow, oxidative stress, and acute inflammatory responses. To overcome these problems, new implant locations as well as new technologies for the production of islets such as induced pluripotent stem cells (iPS cells) are of significant interest, leading to the need for retrievable devices with microenvironments that can support islets function. The objective of this proposal is to develop an intravascular islet delivery and recovery (IIDR) system that will mimic the native islet environment using a thermoresponsive citrate-based macromolecule within a bioengineered vascular conduit.