Analyzing the Immunogenicity of HLA-DQ in solid organ transplantation

Project: Research project

Project Details

Description

SPECIFIC AIMS:
1. Calculated molecular mismatch load in an ethnic-reach cohort of patients who developed de-novo HLA-DQ DSA, using currently available software including HLA Matchmaker, EMS, and PIRCHE-II.
2. Validate an immunogenicity scoring system developed in our laboratory based on a unique 2MM1DSA cohort, based on assigning hierarchy of immunogenicity to different amino acid mismatches.

Goal: To gain better insight into immunogenicity of HLA-DQ mismatches and distinguish those mismatches that are more immunogenic from those that are more likely to be tolerated in the context of solid organ transplantation (focusing first on kidneys)
StatusActive
Effective start/end date12/1/1911/30/20

Funding

  • Vanguard Charitable Endowment Program (Check #736062)

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