Anti-Mullerian Hormone in Pre-Menopausal Women with Epilepsy

Epilepsy is the most common serious neurologic disease affecting women of reproductive age. However, reproductive health in these women has been traditionally understudied. Prior studies indicate that women with epilepsy have reduced fertility, but the reasons for infertility in this population are poorly understood. Clinical evidence of ovarian dysfunction including premature ovarian insufficiency has been reported in women with epilepsy but has not been further evaluated. These preliminary studies suggest that poor ovarian reserve may be responsible for fertility problems in these women. Here we propose to explore the distribution of anti-Mullerian hormone, a novel marker of ovarian reserve, in women with epilepsy. Specifically, we hypothesize that pre-menopausal women with epilepsy are more likely to have reduced levels of anti-Mullerian hormone compared to age-matched controls. This innovative translational approach will identify a potential source of infertility in women with epilepsy and lead the way for further research into the mechanisms of and risk factors for ovarian dysfunction in this population. The results of the study will also have a critical impact on the way we counsel women with epilepsy, who are often implicitly or explicitly encouraged to delay pregnancy without regard to their reproductive options.