Approved Carryover funds for Year 11

    Project: Research project

    Project Details

    Description

    This islet transplantation trial, supported by the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases, and National Institute of Allergy and Infectious Diseases, have fostered development of islet transplantation as a therapeutic treatment for T1D. The aim of this Continuation Award is to complete the existing CIT islet transplant studies, and result in an improved treatment of T1D and licensure of the human islet product. Three study protocols have been developed. as they relate to each protocol are:
    1. To determine the safety and efficacy of peri-transplant administration of the anti-inflammatory agent deoxyspergualin (DSG) on the engraftment and function of pancreatic islet transplants in type 1 diabetic patients (CIT Protocol 03).
    2. To determine the safety and efficacy of a steroid-free, tacrolimus sparing immunosuppressive protocol in type 1 diabetic patients receiving pancreatic islet transplants (CIT Protocol 07).
    3. To determine the efficacy of islet transplantation in type 1 diabetic kidney allograft recipients (CIT Protocol 06).
    StatusFinished
    Effective start/end date9/20/127/31/17

    Funding

    • University of Iowa (2U01DK070431-11)
    • National Institute of Diabetes and Digestive and Kidney Diseases (2U01DK070431-11)

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