Amnestic mild cognitive impairment (aMCI) is a disorder of impaired memory and is a precursor to Alzheimer’s disease, and current treatments are limited. Sleep is linked to cognition: decreased slow wave sleep (physiologically slow wave activity; SWA) is associated with impaired memory. SWA decreases with aging and is even lower in people with aMCI. Interventions that enhance sleep may also improve memory recall. Sound stimulation during sleep increases SWA and memory in young adults and elderly. We have developed a method that analyzes sleep in real time and optimally times the sounds, allowing individualized stimulation. Given that SWA is low in people with aMCI, enhancing SWA may improve cognition. Our objective is to determine if sound stimulation can improve SWA and cognition in aMCI. We propose a randomized sham-controlled cross-over study of this method in people with aMCI. Participants undergo 3 nights of polysomnography (screening, stimulation, and sham) and cognitive testing.
|Effective start/end date
|10/1/15 → 9/30/17
- National Alzheimer's Association (NIRG-15-364483)
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