Bariatric surgery alters estradiol availability and estrogen receptor alpha activity in postmenopausal women

Project: Research project

Project Details

Description

The specific aims are to determine if bariatric surgery in postmenopausal women that results in the loss of 25% of excess body weight:

Aim 1: Alters hormone concentrations in the breast tissue: Estradiol (E2), estrone (E1), testosterone, androstenedione, leptin, adiponectin, 27-hydoxycholesterol (27HC) will be compared in serum and tissue.

Aim 2: Alters ERα mediated genomic DNA-binding events and transcription in breast ductal
epithelial cells

Aim 3: Alters morphology (atypia) and protein expression in duct epithelial cells: adipokines
(leptin, adiponectin), estrogen receptor-alpha (ERα, aromatase, signal activators of transcription 3 (STAT-3)
StatusFinished
Effective start/end date7/1/159/30/16

Funding

  • James Ewing Foundation (AGMT-10/30/15)

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