The specific aims are to determine if bariatric surgery in postmenopausal women that results in the loss of 25% of excess body weight: Aim 1: Alters hormone concentrations in the breast tissue: Estradiol (E2), estrone (E1), testosterone, androstenedione, leptin, adiponectin, 27-hydoxycholesterol (27HC) will be compared in serum and tissue. Aim 2: Alters ERα mediated genomic DNA-binding events and transcription in breast ductal epithelial cells Aim 3: Alters morphology (atypia) and protein expression in duct epithelial cells: adipokines (leptin, adiponectin), estrogen receptor-alpha (ERα, aromatase, signal activators of transcription 3 (STAT-3)
|Effective start/end date||7/1/15 → 9/30/16|
- James Ewing Foundation (AGMT-10/30/15)
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