Bridging Antibody Fc-mediated Antiviral Functions Across Humans and Nonhuman Primates

Project: Research project

Project Details

Description

The primary goal of the Hope Lab in year five of the project is to visually analyze antibody distribution in macaque studies by fluorescent microscopy. The Hope lab will generate fluorescently labeled antibodies and provide them to the primate center. The primate center will conduct all the animal studies and then ship tissues to the Hope lab for analysis. Hope lab personnel will cryosection tissues, stain for cellular markers and image tissues on deconvolution and confocal microscopes. The second goal is to conduct antibody purfication, neutralization, mobility, and binding (SPR) assays.
StatusActive
Effective start/end date5/1/204/30/21

Funding

  • Duke University (A033429//5P01AI120756-05)
  • National Institute of Allergy and Infectious Diseases (A033429//5P01AI120756-05)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.