Cadherin clusters and actin filaments

Project: Research project

Project Details

Description

Our preliminary studies show that cell-cell adhesion is mediated by transient but highly
adhesive cadherin clusters. These clusters are continuously generated by the actin
cytoskeleton at the sites of adhesion. The goal of our proposal is to determine the molecular
mechanism of this process. Some of the mutants obtained in our study are expected to
stabilize cell-cell contacts. Using organotypic keratinocyte culture and Xenopus skin
development, we will explore whether such mutants delay epidermal morphogenesis. These
mutants will be also tested for rescue the adhesion defect induced by anti-desmosome
antibodies. The study is a critical step toward the development of synthetic adhesion
modulators and their application in medicine.
StatusActive
Effective start/end date7/1/165/31/21

Funding

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (5R01AR070166-05)

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