Cardiac fibrosis (scar formation) is a common element of many forms of cardiovascular disease with devastating and often fatal consequences, for which the only effective therapy is organ transplantation. We hope to identify the signals from heart muscle cells that initiate and accelerate cardiac fibrosis, and establish that a protein called BMP7 can prevent the development of scar formation in the heart by silencing these signals following cardiac injury.
|Effective start/end date||4/1/18 → 12/1/19|
- National Heart, Lung, and Blood Institute (5K08HL141659-02 REVISED)
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