Cardiomyocyte TGF-beta: a novel therapeutic target for preventing cardiac fibrosis in humans

  • Flevaris, Panagiotis D (PD/PI)

Project: Research project

Project Details

Description

Cardiac fibrosis (scar formation) is a common element of many forms of cardiovascular disease with devastating and often fatal consequences, for which the only effective therapy is organ transplantation. We hope to identify the signals from heart muscle cells that initiate and accelerate cardiac fibrosis, and establish that a protein called BMP7 can prevent the development of scar formation in the heart by silencing these signals following cardiac injury.
StatusFinished
Effective start/end date4/1/1812/1/19

Funding

  • National Heart, Lung, and Blood Institute (5K08HL141659-02 REVISED)

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