Cerebral Small Vessels in Motor and Cognitive Decline

Project: Research project

Project Details


Cognitive and motor impairments are the two most common causes of disability in older adults.
These two problems can lead to disabling forms of dementia and falls. Age related cognitive and
mobility impairments are clearly multifactorial, but with the rampant incidence of vascular disease in
an aging population we can not underestimate the role of cerebrovascular disease in age related
mobility disability and cognitive decline. Increasing evidence from epidemiological and clinicopathological studies has established a strong link between vascular disease, particularly cerebral
small vessel disease and the age related clinical outcomes of cognitive and mobility impairment.
However, our current research and knowledge is based on surrogate radiographic measure of small
vessel disease which are mostly irreversible. The overall goal of this study is to identify vascular
measures of cerebral small vessels which precede the onset of cognitive and motor decline and are
predictive of clinical and radiographic outcomes in small vessel disease. Such measures would allow
us to indentify individuals in the pre-clinical state when our prevention and therapeutic interventions
could have a higher impact. Moreover, these measures can also be used in future clinical trials to
monitor disease progression and to evaluate new therapies.
Effective start/end date8/1/154/30/19


  • National Institute of Neurological Disorders and Stroke (5R01NS085002-05 REVISED)


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