Project Details
Description
Glaucoma, a group of neurodegenerative eye diseases characterized by retinal ganglion cell death, is the second
leading cause of blindness in the United States. Glaucoma often progresses without obvious symptoms and the
eventual vision loss in glaucoma patients cannot be restored because ganglion cell death is irreversible. Much
remains to be understood about how a retinal ganglion cell dies and how we might prevent this deteriorating
process in glaucoma. In this proposal, we will apply cutting-edge physiology techniques to detect the early signs
of vision loss in glaucomatous mice. We will use mice with high eye pressure to mimic the human high-tension
glaucoma in these tests. We will then examine how these mice gradually lose responses to visual stimulation with
glaucoma progression. The results obtained from these proposed studies may open a potential therapeutic
window to prevent the subsequent cell death and vision loss in glaucoma.
Status | Finished |
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Effective start/end date | 7/1/13 → 6/30/14 |
Funding
- Eversight (Award letter 06/28/13)
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