Characterization of early signs of functional loss of the retina in ocular hypertensive mice

    Project: Research project

    Project Details

    Description

    Glaucoma, a group of neurodegenerative eye diseases characterized by retinal ganglion cell death, is the second
    leading cause of blindness in the United States. Glaucoma often progresses without obvious symptoms and the
    eventual vision loss in glaucoma patients cannot be restored because ganglion cell death is irreversible. Much
    remains to be understood about how a retinal ganglion cell dies and how we might prevent this deteriorating
    process in glaucoma. In this proposal, we will apply cutting-edge physiology techniques to detect the early signs
    of vision loss in glaucomatous mice. We will use mice with high eye pressure to mimic the human high-tension
    glaucoma in these tests. We will then examine how these mice gradually lose responses to visual stimulation with
    glaucoma progression. The results obtained from these proposed studies may open a potential therapeutic
    window to prevent the subsequent cell death and vision loss in glaucoma.
    StatusFinished
    Effective start/end date7/1/136/30/14

    Funding

    • Eversight (Award letter 06/28/13)

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