Characterization of early signs of functional loss of the retina in ocular hypertensive mice

  • Liu, Xiaorong (PD/PI)

Project: Research project

Project Details


Glaucoma, a group of neurodegenerative eye diseases characterized by retinal ganglion cell death, is the second leading cause of blindness in the United States. Glaucoma often progresses without obvious symptoms and the eventual vision loss in glaucoma patients cannot be restored because ganglion cell death is irreversible. Much remains to be understood about how a retinal ganglion cell dies and how we might prevent this deteriorating process in glaucoma. In this proposal, we will apply cutting-edge physiology techniques to detect the early signs of vision loss in glaucomatous mice. We will use mice with high eye pressure to mimic the human high-tension glaucoma in these tests. We will then examine how these mice gradually lose responses to visual stimulation with glaucoma progression. The results obtained from these proposed studies may open a potential therapeutic window to prevent the subsequent cell death and vision loss in glaucoma.
Effective start/end date7/1/136/30/14


  • Eversight (Award letter 06/28/13)


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.