CHEETAH CENTER FOR THE STRUCTURAL BIOLOGY OF HIV INFECTION, RESTRICTION, AND VIRAL DYNAMICS

Project 3: Multiscale Analysis and Modulation of Viral Dynamics The Hope lab at Northwestern University will participate in Project 3 of the CHEETAH Center. The goals of this Project will be to characterize and modulate viral transmission, dissemination, latency, and reactivation across multiple size and resolution scales; from whole-animal studies that will image and characterize latency, rebound and viral dissemination at the cellular and tissue levels, to molecular studies of viral transcriptional transitions, and the design of new biologics delivery systems. The Hope lab will partner with Drs. Ya-Chi Ho, Walther Mothes, and Pamela Bjorkmanin the area of HIV Dissemination, Latency and Reactivation. This will include participating in the 1) identification and imaging of latently infected and reactivating cells in humanized mouse and NHP models and 2) proximity omics of reactivating cells and their immediate neighbors.