In this project, we will test the central hypothesis that the reduction in insulin sensitivity in fat cells of obese women is mediated by perturbations in the daily cycle of gene expression. Furthermore, we will determine the beneficial impact of behavioral adjustment (scheduled sleep and meal times) or bariatric surgery on insulin responsiveness in human adipose tissue samples and explore any racial disparities in the responses obtained. Dr. Knutson is a co-investigator on this project. This project involves assessment of habitual sleep and diet as well as laboratory evaluations. Dr. Knutson has extensive experience assessing habitual sleep using wrist actigraphy and she also has experience analyzing food diary data (currently using this in her funded R01) and laboratory evaluations of sleep and metabolism. Her primary responsibility will be to supervise the actigraphy collection. Further, she will analyze all actigraphy recordings and oversee the export of these data into the stored databases. This project involves up to 12 weeks of actigraphy recordings per subject, depending on the arm of the study. She will also assist with the interpretation of food diary and laboratory data as well as assist with preparation of presentations and manuscripts.
|Effective start/end date||12/1/16 → 7/31/19|
- University of Chicago (FP055658//5R01DK103014-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (FP055658//5R01DK103014-04)