Collaborative Research NSF-ANR: Mechanisms of terminal erythroid enucleation

Project: Research project

Project Details


a. Objectives and research hypothesis a1. Objectives The RedEnuc project aims to decipher the physical mechanisms at play in enucleation during mammalian erythropoiesis: the process red blood cells (RBCs) are generated. Our general objective is to elucidate the role of the mechanical constraints exerted on the erythroblasts / nascent reticulocytes on the extrusion and detachment of nuclei. Our specific objectives are: 1. To develop an in vitro approach to quantitatively measure the physical forces experienced by erythroblasts and nascent reticulocytes, 2. To highlight the role of the forces experienced in a crowded environment and triggered mechanosensitive response in the cells on nuclear extrusion, 3. To elucidate how external squeezing and shearing forces contribute to nucleus detachment, 4. To develop a multiscale computational model to predict the acto-myosin generated internal active force that drives nucleus extrusion and its dependence on mechanosensing, and to predict the external squeezing and shearing forces that promote nucleus detachment.
StatusNot started
Effective start/end date4/1/233/31/26


  • National Science Foundation (PHY-2210369)


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