Collaborative Research: Uncovering how riboswitches exploit out-of-equilibrium RNA folding pathways to make genetic decisions

Project: Research project

Description

The overarching goals of this proposal are to: (i) Uncover detailed mechanisms of how ligand binding bifurcates out-of-equilibrium RNA cotranscriptional folding pathways to enact genetic decisions in riboswitch RNAs; and (ii) Develop and apply new hybrid experimental-computational frameworks that can reconstruct RNA cotranscriptional folding pathways at the secondary and tertiary structure levels. The education plan focuses on integrating this research into hands-on demonstration activities targeted towards school age children, undergraduate researchers, and the broader scientific community.
StatusActive
Effective start/end date8/15/197/31/22

Funding

  • National Science Foundation (PHY-1914567)

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Riboswitch
RNA Folding
Research
Research Personnel
RNA
Ligands
Education