Combination of IL13Rα2 CAR T cell therapy with PD-1 immune checkpoint blockade for treatment of glioblastoma

Project: Research project

Description

We will explore the prospective of combining IL13Ra2-CAR T cell therapy with a PD-1 immune checkpoint blockade against GBM and other IL13Ra2-expressing malignancies by determining 1) central mechanisms regulating CAR-T cell homeostasis at the tumor site, 2) infiltration into the GBM mass, and 3) PD-1 mediated regulation of IL13Ra2-CAR T cells activity in immune competent mouse models to distinguish the involvement of the immune system and glioblastoma in following aims: A1) To determine the regulation of IL13Rα2-CAR T cell function in the glioblastoma multiforme milieu; A2) To determine the role of the PD-1 blockade in the exhaustion and apoptosis of IL13Rα2-CAR T cells.
StatusFinished
Effective start/end date9/1/178/31/19

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH-17-1-0411)

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Glioblastoma
Cell- and Tissue-Based Therapy
T-Lymphocytes
Therapeutics
varespladib methyl
Immune System
Neoplasms
Homeostasis
Apoptosis