Comparative Effectiveness of Pulmonary Embolism Prevention after Hip and Knee Replacement (PEPPER): Balancing Safety and Effectiveness

Project: Research project

Project Details

Description

The purpose of the study “Comparative Effectiveness of Pulmonary Embolism Prevention after Hip and Knee Replacement (PEPPER)” which is funded through a Patient-Centered Outcomes Research Institute (PCORI) award, is to combine information about effectiveness in preventing blood clots in the lungs and legs with the opinions of patients about the safety of the most commonly employed blood thinners. This work will provide background information to help both patients and their surgeons in deciding which blood thinner would be best to use after hip and knee replacement.

In order to generate enough data to achieve the purpose of PEPPER, approximately 20,000 patients undergoing elective total hip or knee replacements will be enrolled at 25 centers over a period of 3.5 years. The principal investigator is Vincent Pellegrini, M.D, John A. Siegling Professor and Chair of the Department of Orthopaedics at the Medical University of South Carolina.
StatusFinished
Effective start/end date2/1/196/30/19

Funding

  • Medical University of South Carolina (MUSC19-032//PCS-1402-09328)
  • Patient-Centered Outcomes Research Institute (MUSC19-032//PCS-1402-09328)

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