Comparison of Transbronchial, Cryoprobe and Video-Assisted Thoracoscopic Surgery Biopsy for the Diagnosis of Idiopathic Pulmonary Fibrosis

Project: Research project

Project Details

Description

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which progressive scarring of the lung impairs exchange of oxygen and carbon dioxide, leading to death from suffocation. Available therapies for IPF only slow progression of disease while the social, healthcare and economic burden of IPF remains significant.
IPF research requires patients to undergo surgical lung biopsy, but their underlying lung disease is limiting. Risk of post-surgical mortality is estimated between 2% and 6% within 90 days of the procedure. Cryotherapy has been used in the airways, safely, for ~4 decades. More recently, cryotherapy has been used to obtain larger transbronchial biopsies and initial reports suggest this as a viable option for diagnosis of IPF with increased
feasibility in patients with significant respiratory compromise. To date there is no study that directly compares
cryobiopsy to transbronchial bronchoscopic biopsy and to a surgical biopsy. If this approach garners sufficient
tissue, for a histopathological diagnosis it could prove invaluable.
We also aim to collaborate with 2 laboratories in our institution that have expertise in flow cytometry, RNAsequencing
and another who are able to measure activity of Wnt/β-catenin in tissue samples that, when upregulated,
leads to worsened fibrosis. Using the larger volume of human tissue sampling we aim to show that
IPF can be diagnosed conclusively. If more IPF patients are able to participate in research, we will be able to
rapidly adapt our techniques to clinical practice and are likely to advance molecular diagnostics to identify novel
pathways for drug development.
StatusFinished
Effective start/end date7/1/176/30/19

Funding

  • Respiratory Health Association of Metropolitan Chicago (RHA2017-01-IPF)

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