Project Details
Description
In the previous study, TAK-935(OV935) was found to suppress spontaneous seizures as well as SUDEP-like deaths in Scn1a-KO mice. These marked therapeutic effects merit further investigation into the potential mechanisms underlying the effects of TAK-935 to protect Scn1a-KO mice from SUDEP-like death. The main hypothesis to test in this project is the potential effects of TAK-935 on spreading depression (SD), which causes an irreversible depolarizations in brainstem, resulting in terminal events.
| Status | Finished |
|---|---|
| Effective start/end date | 6/1/18 → 6/1/21 |
Funding
- Ovid Therapeutics Inc. (Prot #IS00005188)
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