Compound Testing in Scn1a+/- Dravet Mice

Project: Research project

Description

In the previous study, TAK-935(OV935) was found to suppress spontaneous seizures as well as SUDEP-like deaths in Scn1a-KO mice. These marked therapeutic effects merit further investigation into the potential mechanisms underlying the effects of TAK-935 to protect Scn1a-KO mice from SUDEP-like death. The main hypothesis to test in this project is the potential effects of TAK-935 on spreading depression (SD), which causes an irreversible depolarizations in brainstem, resulting in terminal events.
StatusActive
Effective start/end date6/1/186/1/21

Funding

  • Ovid Therapeutics Inc. (Prot #IS00005188)

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Therapeutic Uses
Brain Stem
Seizures