In the previous study, TAK-935(OV935) was found to suppress spontaneous seizures as well as SUDEP-like deaths in Scn1a-KO mice. These marked therapeutic effects merit further investigation into the potential mechanisms underlying the effects of TAK-935 to protect Scn1a-KO mice from SUDEP-like death. The main hypothesis to test in this project is the potential effects of TAK-935 on spreading depression (SD), which causes an irreversible depolarizations in brainstem, resulting in terminal events.
|Effective start/end date||6/1/18 → 6/1/21|
- Ovid Therapeutics Inc. (Prot #IS00005188)