Project Details
Description
A. Objective 1. To determine the effect and dose-response relationship of test compound treatment on hyperthermia-induced seizures in Scn1a+/- Dravet mice and wild-type littermates.
B. Objective 2. To determine the effect and dose-response relationship of test compound treatment on general activity and anxiety measures in Scn1a+/- Dravet mice and wild-type littermates.
A. Objective 1. To determine pharmacokinetics following oral administration of test compound in chow.
B. Objective 2. To determine the effect and dose-dependence of test compound treatment on survival of Scn1a+/- Dravet mice.
C. Objective 3. To determine the effect and dose-dependence of test compound treatment on spontaneous seizures in Scn1a+/- Dravet mice.
D. Objective 4. To determine the effect of test compound treatment on spontaneous seizures and epileptiform activity in Scn1a+/- Dravet mice.
Status | Finished |
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Effective start/end date | 4/20/17 → 4/19/18 |
Funding
- Ovid Therapeutics Inc. (IS00005188)
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