Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype

Many aspects of the neurosynaptic pathology that mediate the influence of TDP-43 on cognition and behavior are relatively unexplored. Similarly, the influence of microglia activation and immune alterations in this process are unknown. The proposed research will generate a great deal of information on the status of synapses and potential trans-synaptic spread of TDP pathology as well as the role of microglia in these processes and in immune alterations. The findings have the potential to illuminate pathways that can serve as therapeutic targets.