Consortium of Eosinophilic Gastrointestinal Disease Researchers: OMEGA

Project: Research project

Project Details


We aim to: 1) better define the diagnostic and clinical features of these diseases (Project 1); 2) determine whether the level of tissue eosinophils, a parameter that is currently required for disease diagnosis, is an adequate measurement of clinical outcome as it has so far been assumed that the level reflects disease severity and adverse prognosis (Project 1); 3) develop validated clinical outcome metrics (COMs) that can be used to quantitatively monitor disease (Project 1); 4) identify and refine biomarkers on the basis of novel approaches that take advantage of direct procurement of readily accessible diseased tissue that will be subjected to whole-genome transcriptome profiling (Project 1 and Project 2); and 5) develop a personalized and predictive medicine approach to understanding and treating these diseases (Project 1 and Project 2).
Effective start/end date8/15/147/31/19


  • Cincinnati Children's Hospital Medical Center (135408-CT1-OMEGA // 5U54AI117804-05 REVISED)
  • National Institute of Allergy and Infectious Diseases (135408-CT1-OMEGA // 5U54AI117804-05 REVISED)


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