Control of E1 oligomerization regulates E1 function in papillomavirus DNA replication

Project: Research project

Project Details


To work out how the biochemical activities that CSH characterized in the papillomavirus E1 protein affects the in vivo functions of E1. I will utilize our expertise in analyzing viral DNA replication of the HPV 31 genome in human foreskin keratinocytes during the latent and productive stages of the viral life cycle. I will test the E1 mutants that affect phosphorylation sites and protein-protein interaction sites. I will also provide samples from differentiated and undifferentiated HFKs for analysis of expression levels of cellular proteins that may be involved in regulation of the viral DNA replication.
Effective start/end date5/1/154/30/20


  • Cold Spring Harbor Laboratory (55890312//5R01AI114897-05)
  • National Institute of Allergy and Infectious Diseases (55890312//5R01AI114897-05)


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