Core: Implementation for "African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translation" study

Project: Research project

Project Details

Description

The vast majority of pharmacogenomic studies have been conducted on exclusively European decent
populations, thereby precluding the discovery and translation of African American specific genetic variation into
precision medicine. This imbalance in discovery and translational science has hindered our ability to deliver
precision medicine to 1 in 7 Americans. Currently several academic medical institutions are incorporating
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines into practice. Without accounting for
new variants found exclusively in African Americans, clinical recommendations based solely on genetic
biomarkers found in European populations could result in misclassification of drug response in African
Americans. Furthermore, there are several well-established, clinically actionable pharmacogenomic
associations (such as the antiplatelet agent, Clopidogrel) that completely lack discovery efforts in African
Americans. Without both discovery and translational efforts in African Americans, precision medicine for all will
not be a reality. As such, we formed a Transdisciplinary Collaborative Center (TCC) dubbed ACCOuNT
(African American Cardiovascular pharmacogenetic Consortium) to discover novel genetic variants in African
Americans related to clinically actionable cardiovascular phenotypes and to incorporating African American
specific SNPs into clinical recommendations, which can be delivered to physicians at the point of care. We
have partnered with academic institutions, patient organizations, and African American community leaders in
both Chicago and in the District of Columbia (DC) to developed our focused effort in precision medicine.
The TCC will consist of four cores (Administrative, Consortium, Implementation, and Data Analysis and
Harmonization) as well as two research projects focused on discovery and translation of genetic findings. The
primary aims of this proposal are: 1) Establish an African Ancestry pharmacogenomics research network to
facilitate genomic research and to establish a public genomics resource for continued translational research; 2)
Establish mechanisms to support implementation, diffusion, and continuing evaluation and improvement of
precision medicine in African Americans; and 3) Engage community leaders in African American
pharmacogenomic research.
Our proposed TCC will be focused on closing this gap in precision medicine by undertaking discovery projects
centering on SNP discovery in African Americans and clinical translational initiatives that will assess the impact
of genetic biomarkers on clinical outcomes in African Americans in an inpatient setting. This model will
establish a pipeline in which basic sciences discovery can pass quickly into clinical translational studies, which
will in turn supply the needed clinical outcomes for implementation. We have incorporated patient centered
approaches to each of these initiatives and have begun to work within African American communities on the
design, recruitment and dissemination of this important work.
StatusActive
Effective start/end date8/19/165/31/21

Funding

  • National Institute on Minority Health and Health Disparities (1U54MD010723-01)

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