Cortico-hippocampal mechanisms of context memory

  • Jovasevic, Vladimir (PD/PI)

Project: Research project

Project Details


Taking advantage of state-of-the art new genetic manipulations and circuit approaches, my main goals are to design protocols related to (a) memory tests to fully address the scope of the involvement of the cytoskeleton-associated genes, and specifically those related to the primary cilium-associated genes, including contextual, tone-dependent, and trace fear conditioning, as well as extinction of the acquired behaviors; (b) tests for anxiety- and depression-like behavior including elevated-plus maze, dark/light emergence, open field, sucrose preference, and social interactions; (c) evaluate the effects of the genetic and circuit manipulations on morphology and the function of primary cilium; (d) investigate the molecular mechanisms through which primary cilium contributes to memory consolidation at the subcellular level using in vitro approaches (cultures of primary hippocampal and cortical neurons, fixed and live cell confocal microscopy, gene and protein expression analyses).
Effective start/end date9/1/202/28/21


  • Albert Einstein College of Medicine (311838 & 311839 // 7R01MH108837-06 & 7R01MH078064-15)
  • National Institute of Mental Health (311838 & 311839 // 7R01MH108837-06 & 7R01MH078064-15)


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