CRAC channels in amyloid-induced calcium dysregulation in Alzheimer's disease

Project: Research project

Project Details

Description

Calcium homeostasis is dysregulated in AD, but there is debate about whether this is a cause or consequence of
neuronal dysfunction, and concerning how amyloid pathology causes neuronal calcium dyshomeostasis. We
observe that high concentrations of Aß42 elevate calcium in primary neurons and in dystrophic neurites around
plaques, and preliminary data indicate that the calcium release-activated calcium (CRAC) channels may play a
role. We will validate the role of CRAC channels in Aß42-induced caclium elevation in neurons, AD mouse models
and AD brain tissues to determine the potential of CRAC channels as a novel therapeutic target in AD.
StatusFinished
Effective start/end date7/1/156/30/16

Funding

  • Illinois Department of Public Health (63282001D)

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