Creation and validation of a pre-biopsy nomogram for predicting high-risk prostate cancer in African American men

Project: Research project

Description

An AA-tailored clinical prediction model will have improved discrimination relative to the PCPT RC for predicting Gleason >6 PCa in AAM undergoing prostate biopsy. Rationale: Many AAM undergo prostate biopsy unnecessarily and many others defer biopsies due to medical mistrust which could be ameliorated with a tailored RC for predicting high-risk PCa.[Halbert CH, Cancer, 2009] Thus, we will innovatively compare the effectiveness of the PCPT RC for high-risk PCa in AAM vs. EAM, tailor and internally validate a model from a retrospective AAM cohort and assess the performance of the AA-tailored prediction model relative to the PCPT RC in prospective recruited AAM eligible for prostate biopsy.
StatusActive
Effective start/end date9/15/179/14/20

Funding

  • U.S. Army Medical Research and Materiel Command (W81XWH-17-1-0608)

Fingerprint

Nomograms
African Americans
Prostatic Neoplasms
Biopsy
Prostate
Neoplasms