CXCR4 Chemokine Receptor Signaling in Painful Diabetic Neuropathy

Project: Research project

Project Details


Diabetes affects 25.8 million people in the USA equivalent to 8.3 % of the US population (1). Neuropathic pain is a debilitating affliction present in 26% of diabetic patients (2) with devastating physical, mental and social health consequences (3). Despite this significant impact and prevalence, current therapies for neuropathic pain are only partially effective (4). Moreover, the molecular mechanisms underlying neuropathic pain in diabetes are not well understood.
Understanding the pathogenesis and the molecular mechanisms underlying neuropathic pain is a critical barrier to further progress in this field, as emphasized by the failure of numerous potential therapeutic approaches to successfully treat this syndrome. Indeed, among all the disorders associated with neuropathic pain, diabetes is the most prevalent. Therefore, given the magnitude of neuropathic pain in diabetes and the absence of effective therapies, the research object of this proposal is to elucidate the molecular mechanisms responsible for induction of neuropathic pain in association with diabetes as a critical step towards possible new and more effective targeted therapeutic interventions
Effective start/end date1/1/1312/31/14


  • Northwestern Memorial Foundation (Fully-executed 12/17/12)


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