Development of a BMP-2-binding demineralized bone nanomatrix (DBN) for spinal fusion

Project: Research project

Description

In this study, we will utilize our BMP-2 direct binding nanogel (BMP-2PA) in conjunction with a DBM powder, to create a demineralized bone nanomatrix (DBN).This combination will harness the mechanical strength of the DBM as well as its additional source of growth factors, while retaining all the advantages that a nanomatrix provides. We believe this approach will lead to reproducible, exogenous growth factor-free fusion in a rat spinal arthrodesis model.
StatusFinished
Effective start/end date5/1/147/31/15

Funding

  • Lumbar Spine Research Society (LSRS2014)

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Spinal Fusion
Intercellular Signaling Peptides and Proteins
Bone and Bones
Arthrodesis
Powders
NanoGel