Development of GlcNAc as disease modifying treatment for Parkinson's Disease

Project: Research project

Description

In patient-derived midbrain neurons we propose to investigate whether N-acetyl-glucosamine (GlcNAc) supplementation can serve as a novel approach to enhance N-linked protein glycosylation which in turn will improve enzyme trafficking, ALP function, and reduce a-syn (Fig 1).Such an approach would be of high interest, since GlcNAc is already available as a dietary supplement and there is little concern about its potential side effects. If GlcNAc supplementation rescues PD models, we can move these studies into α-syn mouse models and ultimately in the clinics.
StatusActive
Effective start/end date1/1/1912/31/19

Funding

  • Northwestern Memorial Hospital (Awrd 2/22/2019)

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Glucosamine
Dietary Supplements
Mesencephalon
Glycosylation
Parkinson Disease
Neurons
Enzymes
Therapeutics