Development of MRI Imaging to Quantitate Inflammation and Bone Destruction in Preclinical Murine Models of RA-like Disease

Project: Research project

Project Details


Northwestern University has established itself as one of the leading institutions for small animal imaging as we have one of the few 9.4T micro-MRIs. We have shown using this MRI the ability to quantitatively assess inflammation and bone destruction in ankle joints in a chronic model of RA-like disease (KBxAg7). Our goal in this proposal is to extend these studies using the collagen induced arthritis model with and without current therapeutics including etanercept or methotrexate. Since in RA patients, macrophage number is an indicator of a successful outcome, we will monitor monocytemacrophage trackingretention using MRI via uptake of iron oxide nanoparticles or liposomes (either administered systemically or used to exogenously label monocytes). These data will demonstrate that MRI modality is optimal for longitudinal preclinical studies that require the examination of multiple parameters in a single mouse during the course of inflammatory arthritis.
Effective start/end date9/6/139/30/17


  • Pfizer Inc. (Agmt 10/29/13)


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