Development of Multienzyme Antibody-Enzyme Conjugates for Prodrug Therapy

Project: Research project

Project Details

Description

Chemotherapy, in which toxic drugs are used to stop or slow the division of cancerous cells, suffers greatly from off-target effects. These drugs circulate throughout the body and are not able to tell the difference between a cancer cell and a healthy cell—indeed many healthy cells also receive the toxic chemotherapeutics. This limits the amount of drug that a patient receives, in order to minimize damage to healthy cells. A therapy is needed that is intelligent; a smart drug would specifically find cancer cells as it circulates through the body, leaving healthy cells untouched. Our goal is to make a protein therapeutic that finds a tumor and converts a nontoxic molecule, a pro drug, to a toxic drug only inside the tumor.
StatusFinished
Effective start/end date7/1/18 → 1/2/19

Funding

  • American Cancer Society (PF-18-118-01-CDD)

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