This is a two-year project to investigate AAV-mediated gene delivery approached to the motor cortex such that selective transduction of upper motor neurons can be achieved with one-time motor cortex injection. It involves both the motor cortex of mouse model and macaque monkey so that translational efforts can be developed in the near future. This is also a collaborative project with Dr. Hatsopoulous at University of Chicago, an expert on cortical connectivity in non-human primates.
|Effective start/end date||7/16/20 → 7/15/22|
- Spastic Paraplegia Foundation, Inc. (Award 09/11/2020)