Study Rationale: Parkinson’s disease (PD) begins decades before it compromises the ability to move about in the world and sleep through the night. Understanding how the dysfunction of brain circuits begins and then evolves to cause difficulty in moving and sleeping will allow us to diagnose PD earlier – increasing our chances of halting disease progression – and to better treat the disease once it appears. Hypothesis: The progressive damage to dopamine-releasing neurons results in staged disruption of neural circuits in larger and larger parts of the brain, ultimately leading to both motor and sleep deficits characteristic of PD. Impact on Diagnosis/Treatment of Parkinson’s disease: A better understanding of how the circuit dysfunction underlying PD is staged should allow earlier diagnosis – enhancing the potential benefit of disease-modifying therapies – and better treatment strategies for later stage patients.
|Effective start/end date||11/1/21 → 10/31/24|
- Michael J. Fox Foundation for Parkinson's Research (ASAP-020551)
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