Aim 1: Confirm that D1- and D2-SPN ensemble dynamics undergo distinct transformations during reinforcement learning. Aim 2: Establish the inter-relation of striatal dopamine transmission and the transformations in D2-SPN ensemble dynamics associated with reinforcement learning. Aim 3: Determine whether in vivo Ca2+ and immediate early gene (IEG) expression dynamics predict changes in the strength of excitatory synaptic connections in D2-SPNs.
|Effective start/end date||1/1/20 → 12/31/22|
- Whitehall Foundation, Inc. (2019-12-70)
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