Drug at the Right Place & Concentration: Optimizing Combination Vaginal Ring...

The work in the laboratory of Dr. Kiser will involve the development of models that describe the mobility of the drugs and viruses within the different compartments from the vaginal delivery and crossing of the vaginal tissue up to the blood. The model will involve the development of multiscale theoretical methodologies that involve all the different process that are relevant for the transport process. It is important to emphasize that the models for the drug and the virus are not the same due to the intrinsic differences in the size and interactions of the drug and the virus. Once the theoretical model is developed then extensive simulations will be carried out and compare directly with the experimental observations. Through an iterative approach between theory and experiments we will develop a quantitative model and address what are all the rate determining steps for different transport in the vaginal tissue.