Drug at the Right Place & Concentration: Optimizing Combination Vaginal Ring PrEP

Project: Research project

Project Details


In Year 4, the laboratory of Dr. Kiser will continue to develop models describing transport of
drug and virus within the reproductive tract, basing model parameters on drug permeability and
partitioning data obtained in our experiments on tissue obtained from the macaque female
reproductive tract. Both simple 2-D models and models based on actual digitized image tissue
slices are currently being developed. We will also continue to obtain experimental data to help
us further refine our models. These models will help us answer important questions in
understanding the prevention of HIV transmission using an intravaginal ring. In addition, we will
continue to improve the design of our TDF IVR to make the wall opaque, add contraceptive
abilities, and make the release more constant.
Effective start/end date1/1/1612/31/17


  • Albert Einstein College of Medicine, Inc. (31097B//5U19AI103461-04)
  • National Institute of Allergy and Infectious Diseases (31097B//5U19AI103461-04)


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