Drug at the Right Place & Concentration: Optimizing Combination Vaginal Ring PrEP

Project: Research project

Project Details

Description

In Year 4, the laboratory of Dr. Kiser will continue to develop models describing transport of drug and virus within the reproductive tract, basing model parameters on drug permeability and partitioning data obtained in our experiments on tissue obtained from the macaque female reproductive tract. Both simple 2-D models and models based on actual digitized image tissue slices are currently being developed. We will also continue to obtain experimental data to help us further refine our models. These models will help us answer important questions in understanding the prevention of HIV transmission using an intravaginal ring. In addition, we will continue to improve the design of our TDF IVR to make the wall opaque, add contraceptive abilities, and make the release more constant.
StatusFinished
Effective start/end date1/1/1612/31/17

Funding

  • Albert Einstein College of Medicine, Inc. (31097B//5U19AI103461-04)
  • National Institute of Allergy and Infectious Diseases (31097B//5U19AI103461-04)

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