These studies are to understand how the proteostasis network protects and prevents Tau aggregation. We will develop a collection of proteostasis reporters to quantify each arm of the proteostasis network in human neuronal and animal models of Tauopathy, to determine when molecular failure occurs leading to Tau aggregation, and use these reporters to test and validate small molecules that modulate the proteostasis network to restore cellular function and reduce TAU proteotoxicity
|Effective start/end date||6/19/20 → 8/31/22|
- Rainwater Charitable Foundation (AGMT 10/19/2021)
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