Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders

Project: Research project

Project Details

Description

Drs. Chen and Miller co-direct the Foundations of Health Research Center and will contribute jointly to this project, including: (a) advise on the collection, processing, and shipment of blood samples; (b) oversee the conduction of peripheral blood and cord blood immunology assays at all 5 time points. These assays will be conducted in their research center; (c) supervise quality control checks on these data; (d) provide guidance about interpretations related to stress-immunology data; and (e) participate in statistical analyses and manuscript preparation.

To index low-grade inflammation, we will measure serum concentrations of C-reactive protein (CRP) and the cytokines interleukins-6, 8, 10, and tumor necrosis factor-alpha. All of these molecules are widely utilized biomarkers of inflammation. These assays will all be conducted at Northwestern University under the direction of Drs. Chen and Miller.
StatusActive
Effective start/end date5/22/184/30/23

Funding

  • Washington University St. Louis (WU-19-11-MOD-3//5R01MH113883-03)
  • National Institute of Mental Health (WU-19-11-MOD-3//5R01MH113883-03)

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