Effect of Injury Severity and Location on Spasms Post SCI

Project: Research project

Project Details

Description

My dedication to spinal cord injury (SCI) comes from both my clinical and academic experiences. As a clinician, I specialized in improving the overall function of persons with SCI and teaching other clinicians specialized treatments for SCI. As an academic, I have had extensive and broad research experiences in SCI. I started working in human SCI research first examining bone mineral density changes post injury at the University of Iowa and then studying the spinal circuitry changes occurring post SCI that contribute to spams at the Rehabilitation Institute of Chicago. My experience with human SCI research and my experiences in the clinic prompted my return to academia full-time to use research to improve the lives of individuals with spinal cord injury (SCI) as my main focus. During my PhD with Jack Kessler, MD, my emphasis was toward interventions. I used developmental neurobiological approaches to attenuating or solving SCI including neural and oligodendritic replacement with embryonic stem cells and axon regeneration with growth factors and development-inspired nanotechnology materials. In performing these studies with my experience as a physical therapist, I saw a great need to develop specific quantitative behavioral tests so we can prove not only that our interventions work, but how exactly they contribute to function. My postdoctoral fellowship with Matt Tresch, PhD, aimed at developing such tests. At present, we have pioneered several new techniques for looking at in vivo mouse behaviors including chronic multi-muscle EMG recordings and single motor unit recordings in the mouse. The spectrum of neuroscientific areas and techniques in which I have experience is quite broad, however, the one piece that is missing is the ability to examine neuronal function using cellular electrophysiology. My short-term career goal is to fill this gap. This proposal provides the expertise and protected time for this learning to occur. Once I am able to perform the techniques listed in my proposal and combine these with my previous experimental knowledge and clinical experience, I will be uniquely qualified for my long-term goal of producing a comprehensive, translatable spinal cord injury research program that is based on novel therapeutics and a basic science understanding of how recovery can be improved, not only on a cellular basis, but on a systems basis as well.
Mentorship for this award and for the beginning of my career is found here at Northwestern as well as at outside institutions. I began my position as an Assistant Professor in the Departments of Physical Therapy and Human Movement Sciences Physiology at Northwestern University in 2013. The PTHMS and Physiology departments are very supportive of my research, as my position requires at most 20% teaching and research space within the Physiology Department. I have shared space and equipment with my consultant, Matt Tresch, PhD for my proposed in vivo behavioral experiments as well as for space and equipment for the proposed in vitro cellular electrophysiology experiments from my mentor, CJ Heckman, PhD. Again, my goal is always to design my experiments to be as clinically relevant as possible and my clinical experience supports this goal, but my chairperson and consultant Jules Dewald, PT, PhD, will also be evaluating my work for translatability as this is clearly a strength for him. Finally, two outstanding researchers, Ron Harris-Warrick, PhD at Cornell University and Claire Meehan, PhD at the University of Copenhagen will provide mentoring outside of Northwestern. They have both g
StatusActive
Effective start/end date8/7/155/31/21

Funding

  • National Institute of Child Health and Human Development (5K01HD084672-05)

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