Effect of Low Dose Methotrexate on Arterial Inflammation in HIV

Project: Research project

Project Details


A5314 is a phase II, randomized, double-blind, placebo-controlled trial to
evaluate the safety and efficacy of low dose methotrexate (LDMTX) for the
treatment for HIV-associated inflammation. The ancillary study will assess
the impact of anti-inflammatory treatment with LDMTX on arterial
inflammation, as assessed by FDG-PET/CT imaging in virally suppressed
HIV-infected individuals already taking part in the main A5314 protocol.
Effective start/end date8/31/155/31/17


  • Massachusetts General Hospital (224883 / R01HL122177)
  • National Heart, Lung, and Blood Institute (224883 / R01HL122177)


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