Effect of SOD Mimetics on Wound Healing and Hypertrophic Scarring

Wound repair is a complex and dynamic process which consists of inflammation, angiogenesis, and tissue formation and remodeling. Dysregulation of this process often result in impaired cutaneous wound healing. Hypertrophic scars are a frequent and unwanted consequence of cutaneous trauma, burns or surgery. The dysregulation of oxygen metabolic pathways contribute to a number of pathologies, including fibrosis, cancer, inflammation and mitochondria dysfunction. Overproduction of reactive oxygen species (ROS) impairs healing process of wounds. Thus, modulation of oxygen metabolic pathways offers opportunities for enhancing wound healing and reducing hypertrophic scars