Effect of the KLOX Biophotonics system on wound healing

Project: Research project

Project Details

Description

Wound repair is a complex and dynamic process which consists of inflammation, angiogenesis, and tissue formation and remodeling. Upon injury, fibrin clots are deposited on the wound site to prevent hemorrhage. Circulating platelets migrate to the wound and release inflammatory signals such as transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF). This is followed by the infiltration of neutrophils and macrophages and the migration of keratinocytes to the wound to recover the barrier function of skin. Endothelial cells and fibroblasts migrate to the site and build up granulation tissues by depositing collagen and other extracellular matrices. During the final stages of repair, fibroblasts and macrophages remodel the collagen by producing matrix metalloproteinases (MMPs) over a course of several months. Thus wound repair is a highly orchestrated sequential process in which signals of one cell type regulate other cell types in a cascade. Dysregulation of these processes often result in impaired cutaneous wound healing. Light has been used throughout history to treat countless health conditions. KLOX Technologies has succeeded in evolving the use of light in therapeutic treatments to a new level. It has developed an innovative technology platform; the KLOX Biophotonic system, which consists of a primary multi-LED light device and a patent pending topical photo converter gel, with applications in dermatology, dentistry, and wound treatment. The element-rich photo converter gel is applied to the area being treated, which is then illuminated by the lamp. The interactions that take place aid in the creation of an environment favoring repair. We will investigate whether the KLOX Biophotonic system improves wound healing using the rabbit ear wound models.
StatusFinished
Effective start/end date11/27/1311/27/16

Funding

  • KLOX Technologies, Inc. (Agmt 11/27/13)

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