Effects of XPC-5462, NBI921353, NBI921354, and NBI921355 on SCN2A (NaV1.2) gain-of-function (GOF) variants (hereinafter "Project")

Project: Research project

Project Details

Description

To investigate the effects of novel sodium channel blockers on human and rat SCN2A (NaV1.2) gain-of-function (GOF) variants. Variants were selected to represent diverse locations within the channel protein and diverse GOF mechanisms.
StatusActive
Effective start/end date3/28/229/27/22

Funding

  • Neurocrine Biosciences, Inc. (NB AGMT 3-28-22)

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