Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects

Project: Research project

Project Details

Description

Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma in the US. Two thirds of cases are cured with standard chemoimmunotherapy. However, patients with high risk features or patients with refractory or relapsed DLBCL (R/R DLBCL)have a 5-year overall survival rate of only 33%.1 Double hit or high grade B cell lymphomas or R/R DLBCL are clinically challenging to manage with 35% overall survival at 2 years despite modern therapies. Thus, finding novel innovative approaches to improve these numbers is an important unmet need.

Specific Aim 1: Optimization of a nanoparticle platform for CpG delivery for the treatment of lymphoma
Sub-aim 1.1: To engineer an optimized stable Class C CpG NP and screen for maximum anti-lymphoma effects in vitro.
Sub-aim 1.2: To determine if class C tmCpG NPs can trigger a systemic anti-tumor immune response
Specific Aim 2: To evaluate photothermal therapy using hollow gold nanoshells (HGNs) as an in situ vaccination method for lymphoma therapy
StatusActive
Effective start/end date7/1/206/30/22

Funding

  • Lymphoma Research Foundation (Agmt 3/13/20)

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