Cerebral palsy (CP) describes a heterogeneous collection of non- progressive motor disorders secondary to perinatal brain injury. Perinatal brain injury in premature infants is well studied, but there is little information regarding injury in intrauterine growth restricted (IUGR) infants. The most common cause of IUGR in developed countries is maternal preeclampsia. A new mouse model of IUGR mimics the human condition of preeclampsia by utilizing an analog of thromboxane A2 (TXA2), which is expressed at 10-fold higher levels in women who develop preeclampsia during pregnancy. This study will use intrauterine exposure to TXA2 to mimic the effects of IUGR on white matter development. The model will also examine the effect of hyperoxia in combination with IUGR, as IUGR babies often experience respiratory insufficiency following birth, requiring prolonged exposure to high oxygen levels. White matter tracts will then be studied utilizing digital gain analysis, diffusion tensor MRI and electron microscopy to assess if motor dysfunction results from decreased brain connectivity due to abnormal myelination (white matter formation).
|Effective start/end date||9/1/16 → 8/31/17|
- Northwestern Memorial Hospital (Agmt Signed 09/01/16)