Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established Disease

Although current therapies can generally control many of the signs and symptoms of rheumatoid arthritis, there remains a critical need to improve treatment for patients so that remission, cure and/or prevention are routinely possible. The availability of new technologies and experimental tools to study the signaling alterations and molecular mechanisms that drive this disease provides an opportunity to achieve these goals. This proposed study will focus on identifying novel targets and pathways for therapeutic intervention in this disease.